Background. Decellularized human skin has been used in a variety of medical applications, primarily involving soft tissue\nreconstruction, wound healing, and tendon augmentation. Theoretically, decellularization removes potentially immunogenic\nmaterial and provides a clean scaffold for cellular and vascular in growth. The use of acellular dermal matrix in two-stage\npostmastectomy breast reconstruction is described. Methods. Ten consecutive breast cancer patientswere treated with mastectomies\nand immediate reconstruction from August to November 2011. There were 8 bilateral and 1 unilateral mastectomies for a total of 17\nbreasts, with one exclusion for chronic tobacco use. Reconstruction included the use of a new 6 Ã?â?? 16 cm sterile, room temperature\nacellular dermal matrix patch (DermACELL) soaked in a cefazolin bath. Results. Of the 17 breasts, 15 reconstructions were\ncompleted; 14 of them with expander to implant sequence and acellular dermal matrix. Histological analysis of biopsies obtained\nduring trimming of the matrix at the second stage appeared nonremarkable with evidence of normal healing, cellularity, and\nvascular infiltration. Conclusion. Postoperative observations showed that this cellular dermal matrix appears to be an appropriate\nadjunct to reconstruction with expanders. This acellular dermal matrix appeared to work well with all patients, even those receiving\npostoperative chemotherapy, postoperative radiation, prednisone, or warfarin sodium.
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